Impact of Subthalamic Deep Brain Stimulation on Hyposmia in Patients With Parkinson's Disease Is Influenced by Constipation and Dysbiosis of Microbiota

Background: Non-motor symptoms in PD usually arise at very early stage and vary during the whole disease progression. Deep brain stimulation (DBS) is considered as a highly efficient treatment option for PD's motor function. However, effect of DBS on NMS, especially hyposmia, has not been fully understood deep connection between different NMS such hyposmia constipation still unknown. Objective: The objective this study was to evaluate therapeutic patients with or without find potential factors which might influence efficacy. Methods: A retrospective analysis 65 accepted STN-DBS operation Qilu Hospital 2019–2020 were conducted exact PD. Sub-group analyses about relationship carried out. Analysis flora nasal mucosa also abundance variety groups. Results: Our showed that had clearly improved olfactory function Parkinson ( P = 0.012) subgroup found have lower scores (25.27 ± 3.44 vs. 33.90 6.633, p 0.014) worse improvement after (ΔTDI 12.11 3.2 8.78 2.91, 0.0072). indicated obvious discrepancy degree be related dysbiosis microbiota. Conclusion: In summary, article presents operation, explored offer explanation why less